Cell state · L2
B.germinal_center.DZ_S_phase
164 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CDT1, DCTPP1, DHFR, DUT, GINS2, MCM3, MCM34, MCM5, MCM7, MSH6, PCNA, POLE3, RANBP1, RFC2, RFC4, RNASEH2A, SLBP, UNG
Annotation genes
DHFR, MSH6, PCNA, UNG
Annotation rationales
Dominated by DNA replication machinery (MCMs, PCNA, DHFR) and repair/SHM factors (UNG, MSH6). This reflects centroblasts in the DNA synthesis phase, where replication is tightly coupled to somatic hypermutation.
Functional implications
Drives clonal expansion with SHM licensing, enabling generation of diverse antibody variants in the dark zone that later undergo affinity-based selection in the light zone.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.