Cell state · L2
B.germinal_center.DZ_M_phase
103 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ASPM, AURKB, CDC20, CDCA3, CDCA8, CDK1, CENPF, DLGAP5, GTSE1, KIF23, KNSTRN, NUSAP1, PLK1, SGO2, TOP2A, UBE2C
Annotation genes
AURKB, CDC20, CDK1, PLK1, TOP2A
Annotation rationales
High expression of mitotic spindle and checkpoint regulators (AURKB, CDC20, CDK1, PLK1, TOP2A) marks centroblasts in the dark zone at the M-phase of the cell cycle. These genes coordinate chromosome segregation and spindle assembly, distinguishing this set from the S-phase proliferative program.
Functional implications
Amplifies GC clones through rapid mitoses, ensuring a sufficient pool of diversified B cells for subsequent rounds of selection and differentiation into memory or plasma fates.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.