Cell state · L2
B.age_associated.migratory
563 cells in the full atlas (not the displayed sample).
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Marker genes
ANXA2, ARPC1B, CAPZB, CD82, CIB1, COTL1, CRIP1, GAPDH, ITGB7, LSP1, SH3BGRL3, SUB1, TAGLN2, UCP2
Annotation genes
ANXA2, ARPC1B, CAPZB, CD82, COTL1, ITGB7, LSP1, TAGLN2, UCP2
Annotation rationales
Strong expression of actin-remodeling and adhesion molecules (LSP1, TAGLN2, COTL1, ARPC1B, CAPZB) indicates capacity for immune-synapse formation and migratory behavior. CD82 (tetraspanin) and ITGB7 support tissue homing and mucosal retention. ANXA2 promotes cytoskeletal rearrangements, while UCP2 signals metabolic adaptation to oxidative stress—common in chronically stimulated ABCs. This constellation highlights ABCs with heightened mobility and immune-synapse readiness.
Functional implications
Functions as tissue-patrolling ABCs, able to migrate into inflamed niches and form stable immune synapses with T cells or antigen-presenting cells. They support local recall responses, particularly in non-lymphoid tissues, and maintain resilience under metabolic/oxidative stress. This equips them to persist during chronic inflammation and contribute to immune surveillance in aged or repeatedly challenged hosts.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.