Cell state · L2
B.age_associated.activated
451 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CD72, CD83, CREM, DUSP2, FCRL5, NR4A1, NR4A2, NR4A3, SH3BP2, SREBF2, SRGN, TUBB2A, TXNDC5, ZNF331
Annotation genes
CD72, CD83, CREM, DUSP2, FCRL5, NR4A1, SH3BP2, SREBF2
Annotation rationales
NR4A family (NR4A1/2/3) are immediate-early genes induced by strong BCR/TLR stimulation, indicating acute antigen experience; DUSP2 and CREM provide negative feedback to dampen MAPK/NFAT pathways, limiting overactivation. FCRL5 is a hallmark of ABCs/atypical memory B cells linked to chronic stimulation and autoimmunity. CD83 and SH3BP2 reinforce activation status, while CD72 adds inhibitory signaling. SREBF2 reflects metabolic reprogramming toward cholesterol and membrane remodeling, needed for sustained signaling and plasmablast differentiation. Altogether, this profile captures ABCs in an activated but self-attenuating state characteristic of chronic antigen exposure.
Functional implications
Represents recently antigen-triggered ABCs that balance activation with self-limiting signals. They remain responsive in contexts of persistent antigen (e.g. aging, chronic infection, autoimmunity) while avoiding terminal exhaustion. These cells may regulate chronic immune activation by contributing to cytokine production and antigen presentation while restraining full effector differentiation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.