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Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

MAC.MDM.complement_resolving: Gene expression — page 28

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links
Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant
The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1)
Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2)
Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values
CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits
Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links
Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support
The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support
The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority
Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority
Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation
Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation
A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

State · 1,931 full-atlas cells · all tissues.

Marker genes and cell annotation · Open this population in Cell Browser →

Mean expression uses the current overview’s precomputed gene means from the displayed 10,000-cell sample, matching the overview gene-ranking panel. These are not full-population means and are not IC scores. Every gene with a finite value is included, including zero expression.

Rows 27,001–28,000 of 28,231; ranked by score descending. Equal values use name/identifier order.

Gene expression ranked for MAC.MDM.complement_resolving
Browsers#GeneMean expressionMeta traits (High Priority)Individual traits (High Priority)
27001TXLNB0.0047
27002TXLNG0.00——
27003TXNDC12-AS10.00——
27004TXNDC20.0025
27005TXNDC50.00916
27006TXNDC80.0000
27007TXNDC90.0000
27008TXNL4B0.00104231
27009TXNRD30.001126
27010TYK20.003576
27011TYMS0.0055
27012TYR0.0000
27013TYRO30.00422
27014TYRP10.0011
27015TYW1B0.0013
27016U2AF1L50.00——
27017U47924.20.00——
27018U47924.30.00——
27019U52111.10.00——
27020U62317.20.00——
27021U62317.30.00——
27022U73166.10.00——
27023U91319.10.00——
27024U91324.10.00——
27025U91328.20.00——
27026U91328.30.00——
27027U95743.10.00——
27028UACA0.0063
27029UAP1L10.001947
27030UBA10.00——
27031UBA60.0000
27032UBA6-AS10.00——
27033UBAC2-AS10.00413
27034UBALD10.002646
27035UBALD20.0034
27036UBAP1L0.0011
27037UBAP20.0010
27038UBAP2L0.00443
27039UBASH3A0.001749
27040UBD0.001615
27041UBE2C0.00925
27042UBE2E1-AS10.0011
27043UBE2E2-AS10.00——
27044UBE2H0.00423
27045UBE2K0.0010
27046UBE2Q10.00917
27047UBE2Q1-AS10.00——
27048UBE2Q20.0057
27049UBE2Q2L0.00——
27050UBE2QL10.0011
27051UBE2R2-AS10.00713
27052UBE2T0.0000
27053UBE2U0.0013
27054UBE2Z0.003286
27055UBE3C0.00314
27056UBE3D0.0000
27057UBE4A0.001563
27058UBFD10.0000
27059UBIAD10.0000
27060UBL30.0011
27061UBL4A0.00——
27062UBL4B0.00——
27063UBL7-AS10.00——
27064UBN20.00437
27065UBOX50.0012
27066UBOX5-AS10.0001
27067UBP10.00616
27068UBQLN20.00——
27069UBQLN30.00——
27070UBQLNL0.00——
27071UBR30.0054
27072UBR5-AS10.00——
27073UBTD20.00417
27074UBTF0.001355
27075UBXN100.0000
27076UBXN10-AS10.00——
27077UBXN2B0.0024
27078UBXN7-AS10.0000
27079UBXN80.0001
27080UCHL10.0000
27081UCHL1-AS10.00——
27082UCHL30.0000
27083UCK20.0000
27084UCKL1-AS10.001426
27085UCMA0.0000
27086UCN0.00255626
27087UCN20.0000
27088UCN30.0029
27089UCP10.0000
27090UCP30.0011
27091UEVLD0.0011
27092UFD10.0011
27093UFL10.0000
27094UFL1-AS10.00543
27095UFSP10.0057
27096UGCG0.0021
27097UGDH0.001426
27098UGDH-AS10.0077
27099UGGT10.0000
27100UGT1A10.003142
27101UGT1A100.003041
27102UGT1A30.003143
27103UGT1A40.004592
27104UGT1A50.003863
27105UGT1A60.00721
27106UGT1A70.003141
27107UGT1A80.003863
27108UGT1A90.003965
27109UGT2A10.0000
27110UGT2A30.0033
27111UGT2B100.002755
27112UGT2B110.00——
27113UGT2B150.001011
27114UGT2B170.00711
27115UGT2B280.0000
27116UGT2B40.0012
27117UGT2B70.002554
27118UGT3A10.0044
27119UGT3A20.0044
27120UGT80.0005
27121UHRF10.001230
27122UHRF1BP10.00——
27123UHRF1BP1L0.00——
27124UHRF20.0010
27125ULBP10.0000
27126ULBP20.0000
27127ULBP30.0057
27128ULK10.0047
27129ULK20.0026
27130ULK30.0036
27131ULK40.00412
27132UMOD0.00110155
27133UMODL10.0021
27134UMPS0.002125
27135UNC119B0.001729
27136UNC13A0.0089
27137UNC13B0.0000
27138UNC13C0.0039
27139UNC13D0.0070166
27140UNC45B0.0000
27141UNC5A0.0000
27142UNC5B0.0034
27143UNC5B-AS10.0034
27144UNC5C0.0047
27145UNC5CL0.0011
27146UNC5D0.0012
27147UNC790.0000
27148UNC800.0011
27149UNC93A0.0000
27150UNCX0.0024
27151UNG0.0000
27152UNKL0.0037
27153UNQ64940.00——
27154UPB10.001728
27155UPF10.003354
27156UPK1A0.0000
27157UPK1A-AS10.0000
27158UPK1B0.0000
27159UPK20.001736
27160UPK3A0.00510
27161UPK3B0.0001
27162UPP20.0000
27163UPRT0.00——
27164UQCC10.001123
27165UQCRHL0.00429
27166URAD0.001018
27167URB10.0000
27168URB1-AS10.0000
27169URB20.0036107
27170URM10.0033
27171UROC10.001127
27172UROS0.0011
27173USF10.001326
27174USF30.0000
27175USH1C0.0011
27176USH1G0.00313
27177USH2A0.00416
27178USHBP10.00728
27179USMG50.00——
27180USP10.00321
27181USP12-AS10.0036
27182USP12-AS20.00——
27183USP130.0000
27184USP17L20.00——
27185USP17L70.00——
27186USP180.00811
27187USP190.0034
27188USP20.00819
27189USP200.00610
27190USP220.0011
27191USP250.001021
27192USP260.00——
27193USP27X0.00——
27194USP27X-AS10.00——
27195USP280.0078
27196USP290.00——
27197USP3-AS10.0048
27198USP300.0000
27199USP30-AS10.0039
27200USP310.0000
27201USP350.002144
27202USP360.00512
27203USP380.0011
27204USP400.001028
27205USP410.00——
27206USP430.0000
27207USP440.0011
27208USP450.0000
27209USP46-AS10.00——
27210USP490.0034142
27211USP50.001123
27212USP500.0022
27213USP510.00——
27214USP540.001398
27215USP60.0000
27216USP70.0011
27217USP9Y0.00——
27218USPL10.0000
27219UST0.0011
27220UST-AS10.00——
27221UTF10.00814
27222UTP110.00214
27223UTP14C0.0000
27224UTP150.0000
27225UTP180.0001
27226UTP200.0000
27227UTP230.0000
27228UTP40.0000
27229UTS20.0055
27230UTS2B0.00513
27231UTS2R0.00621
27232UXT-AS10.00——
27233VAC140.00810
27234VAC14-AS10.00810
27235VAMP10.001249
27236VAMP40.00311
27237VAMP70.00——
27238VANGL10.00594
27239VANGL20.0023
27240VARS0.00——
27241VARS20.006290
27242VASH1-AS10.00——
27243VASH20.0000
27244VASN0.002875
27245VAT1L0.0000
27246VAV10.001125
27247VAV20.0045
27248VAV3-AS10.0014
27249VAX10.0011
27250VAX20.0011
27251VCAM10.0000
27252VCAN-AS10.00——
27253VCPIP10.0000
27254VCX0.00——
27255VCX20.00——
27256VCX3A0.00——
27257VCX3B0.00——
27258VDR0.001044
27259VEGFC0.0000
27260VEGFD0.00——
27261VENTX0.0034
27262VEPH10.0011
27263VGF0.002134
27264VGLL10.00——
27265VGLL20.0038
27266VGLL30.0058
27267VHLL0.00——
27268VIL10.001592
27269VILL0.00716
27270VIP0.0012
27271VIPAS390.0000
27272VIPR10.0000
27273VIPR1-AS10.0000
27274VIPR20.001014
27275VIRMA0.0022
27276VIT0.0022
27277VKORC1L10.0000
27278VLDLR0.0033
27279VLDLR-AS10.0022
27280VN1R10.0000
27281VN1R20.00——
27282VNN10.0088
27283VNN20.0088
27284VNN30.00——
27285VPREB10.0000
27286VPREB30.00711
27287VPS13A-AS10.0000
27288VPS13B0.0000
27289VPS13D0.001218
27290VPS250.0000
27291VPS33A0.0010
27292VPS33B0.001827
27293VPS360.0000
27294VPS37A0.001629
27295VPS37D0.002141,102
27296VPS390.0001
27297VPS450.0022
27298VPS4B0.0000
27299VPS520.0059
27300VPS540.0031
27301VPS9D10.002950
27302VPS9D1-AS10.002743
27303VRK10.0000
27304VRK30.0058
27305VRTN0.0027
27306VSIG10.00——
27307VSIG10L0.0025
27308VSIG20.0000
27309VSIG80.0011
27310VSNL10.0012
27311VSTM10.001112
27312VSTM2A0.0000
27313VSTM2B0.0000
27314VSTM2L0.0024
27315VSTM40.00718
27316VSTM50.0011
27317VSX10.0000
27318VSX20.0000
27319VTCN10.00619
27320VTN0.00——
27321VWA10.00625
27322VWA20.0000
27323VWA3A0.0000
27324VWA3B0.00——
27325VWA5B10.0000
27326VWA5B20.0011
27327VWA70.0011
27328VWA80.0001
27329VWA8-AS10.0000
27330VWC20.00613
27331VWC2L0.0000
27332VWCE0.0017
27333VWDE0.0000
27334VWF0.006263
27335WAC0.0000
27336WAC-AS10.0000
27337WARS0.00——
27338WARS20.0000
27339WARS2-IT10.00317
27340WASF10.0008
27341WASF30.00614
27342WASF3-AS10.0000
27343WASHC10.001367
27344WASHC5-AS10.0000
27345WASIR10.00——
27346WASIR20.0034
27347WASL0.0079
27348WBP1L0.002366
27349WBP40.001151
27350WDCP0.00535
27351WDFY10.0044
27352WDFY3-AS10.0000
27353WDFY40.0044
27354WDHD10.00217
27355WDPCP0.0049
27356WDR11-AS10.00——
27357WDR120.0011
27358WDR170.0000
27359WDR240.00624
27360WDR260.0011
27361WDR270.0003
27362WDR30.0000
27363WDR310.0022
27364WDR340.00——
27365WDR350.001843
27366WDR360.0000
27367WDR380.0057
27368WDR40.0000
27369WDR440.00——
27370WDR460.001528
27371WDR470.0033
27372WDR480.001417
27373WDR490.0000
27374WDR50.0037
27375WDR530.00617
27376WDR540.0000
27377WDR550.001113
27378WDR5B0.00617
27379WDR60.001122
27380WDR600.00——
27381WDR610.00——
27382WDR620.0038
27383WDR630.00——
27384WDR640.0000
27385WDR660.00——
27386WDR70.0000
27387WDR700.0000
27388WDR720.001649
27389WDR760.0045
27390WDR780.00——
27391WDR810.0096222
27392WDR830.001544
27393WDR860.0047
27394WDR870.0000
27395WDR880.0072313
27396WDR900.00923
27397WDR920.00——
27398WDR930.00517
27399WDR970.0022
27400WDSUB10.0045
27401WDTC10.00511
27402WDYHV10.00——
27403WEE10.001572
27404WEE20.0000
27405WEE2-AS10.0000
27406WFDC10.0012
27407WFDC10A0.0000
27408WFDC10B0.00816
27409WFDC110.0000
27410WFDC120.001223
27411WFDC130.00111
27412WFDC30.0034101
27413WFDC50.001535
27414WFDC60.0004
27415WFDC80.0000
27416WFDC90.00——
27417WFIKKN10.00513
27418WFIKKN20.0000
27419WFS10.00320
27420WIF10.0000
27421WIPF20.001337
27422WIPF30.0000
27423WISP10.00——
27424WISP20.00——
27425WISP30.00——
27426WIZ0.0010
27427WLS0.0004
27428WNK10.0046
27429WNK20.002628
27430WNK30.00——
27431WNK40.0011
27432WNT10.0047
27433WNT10A0.001385
27434WNT10B0.0047
27435WNT110.0011
27436WNT160.0044
27437WNT20.001055
27438WNT2B0.0078
27439WNT30.0034
27440WNT3A0.0000
27441WNT40.0047
27442WNT5A0.001125
27443WNT5A-AS10.00615
27444WNT5B0.00417
27445WNT60.00661
27446WNT7A0.0016
27447WNT7B0.0012
27448WNT8A0.0000
27449WNT8B0.0000
27450WNT9A0.0036
27451WNT9B0.0032131
27452WRAP530.002251
27453WRAP730.0022
27454WRB0.00——
27455WRNIP10.00519
27456WSB20.0000
27457WSCD10.0000
27458WSCD20.0000
27459WT10.00837
27460WT1-AS0.001451
27461WTIP0.0000
27462WWC10.0055
27463WWC20.0012
27464WWC2-AS10.0011
27465WWC2-AS20.0022
27466WWC30.00——
27467WWC3-AS10.00——
27468WWOX-AS10.0000
27469WWP20.001026
27470WWTR10.00516
27471WWTR1-AS10.00413
27472XACT0.00——
27473XAGE1A0.00——
27474XAGE1B0.00——
27475XAGE20.00——
27476XAGE30.00——
27477XAGE50.00——
27478XCL10.00513
27479XCL20.001130
27480XCR10.001226
27481XDH0.0000
27482XG0.00——
27483XIAP-AS10.00——
27484XIRP10.001024
27485XIRP20.0000
27486XK0.00——
27487XKR30.00——
27488XKR40.00421
27489XKR50.0024
27490XKR60.0011
27491XKR70.0038
27492XKR80.00540
27493XKR90.0087
27494XKRX0.00——
27495XPC0.00817
27496XPNPEP10.0010
27497XPNPEP30.0000
27498XPO50.00611
27499XPO60.0001
27500XPOT0.0045
27501XPR10.0025
27502XRCC20.0011
27503XRCC30.00812
27504XRCC40.0000
27505XXYLT1-AS20.0034
27506XYLB0.0032
27507XYLT10.0025
27508XYLT20.0035
27509YAE1D10.00——
27510YAF20.0000
27511YAP10.0022
27512YARS0.00——
27513YARS20.00——
27514YBX20.00815
27515YEATS2-AS10.00——
27516YEATS40.00818
27517YES10.00941
27518YIPF10.0010
27519YIPF70.0000
27520YJEFN30.0048103
27521YLPM10.0011
27522YOD10.001111
27523YPEL10.0011
27524YPEL20.00532
27525YPEL40.002369
27526YRDC0.0000
27527YTHDF20.0000
27528YTHDF3-AS10.00——
27529YY20.00——
27530Z68323.10.00——
27531Z68871.10.00——
27532Z69666.10.00——
27533Z69706.10.00——
27534Z69720.10.00——
27535Z69733.10.00——
27536Z73495.10.00——
27537Z82173.10.00——
27538Z82186.10.00——
27539Z82188.20.00——
27540Z82196.10.00——
27541Z82196.20.00——
27542Z82198.10.00——
27543Z82198.20.00——
27544Z82214.10.00——
27545Z82217.10.00——
27546Z82243.10.00——
27547Z82244.20.00——
27548Z83818.20.00——
27549Z83844.10.00——
27550Z83847.10.00——
27551Z84485.10.00——
27552Z84492.10.00——
27553Z93241.10.00——
27554Z93403.10.00——
27555Z93930.20.00——
27556Z94057.10.00——
27557Z94160.20.00——
27558Z94721.10.00——
27559Z95114.10.00——
27560Z95114.20.00——
27561Z95114.40.00——
27562Z95115.10.00——
27563Z95624.10.00——
27564Z97055.20.00——
27565Z97056.10.00——
27566Z97192.10.00——
27567Z97205.20.00——
27568Z97652.10.00——
27569Z97653.10.00——
27570Z97832.20.00——
27571Z97986.10.00——
27572Z97989.10.00——
27573Z98200.10.00——
27574Z98257.10.00——
27575Z98752.10.00——
27576Z98752.30.00——
27577Z98752.40.00——
27578Z98884.10.00——
27579Z98885.20.00——
27580Z98885.30.00——
27581Z99289.10.00——
27582Z99289.30.00——
27583Z99755.20.00——
27584Z99758.10.00——
27585Z99774.10.00——
27586Z99916.10.00——
27587Z99916.30.00——
27588Z99943.10.00——
27589ZACN0.0011
27590ZADH20.00——
27591ZAN0.001144
27592ZAP700.00——
27593ZAR10.0000
27594ZAR1L0.0011
27595ZBBX0.0000
27596ZBED10.00——
27597ZBED20.0001
27598ZBED3-AS10.0000
27599ZBED5-AS10.0000
27600ZBED6CL0.00——
27601ZBED80.00——
27602ZBED90.00——
27603ZBP10.001268
27604ZBTB10.00624
27605ZBTB100.0066
27606ZBTB110.0022
27607ZBTB11-AS10.0023
27608ZBTB120.002433
27609ZBTB140.0000
27610ZBTB160.003242
27611ZBTB170.001235
27612ZBTB180.0000
27613ZBTB20.0024
27614ZBTB20-AS10.00——
27615ZBTB20-AS20.00——
27616ZBTB20-AS30.0024
27617ZBTB20-AS40.0000
27618ZBTB20-AS50.0011
27619ZBTB210.0010
27620ZBTB220.0010
27621ZBTB240.001567
27622ZBTB30.0000
27623ZBTB320.0000
27624ZBTB370.001022
27625ZBTB380.001961
27626ZBTB390.0025301
27627ZBTB40.001423
27628ZBTB400.0011
27629ZBTB410.0000
27630ZBTB420.0042129
27631ZBTB450.0000
27632ZBTB460.001976
27633ZBTB46-AS10.001032
27634ZBTB470.0000
27635ZBTB490.0000
27636ZBTB50.0000
27637ZBTB60.0000
27638ZBTB7A0.002374
27639ZBTB7B0.001728
27640ZBTB7C0.00512
27641ZBTB8A0.0000
27642ZBTB8B0.0000
27643ZBTB8OS0.0000
27644ZBTB90.0000
27645ZC2HC1A0.0000
27646ZC2HC1B0.00——
27647ZC2HC1C0.001016
27648ZC3H100.0000
27649ZC3H12B0.00——
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