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Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

MAC.MDM.complement_resolving: Gene expression — page 22

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links
Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant
The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1)
Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2)
Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values
CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits
Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links
Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support
The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support
The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority
Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority
Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation
Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation
A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

State · 1,931 full-atlas cells · all tissues.

Marker genes and cell annotation · Open this population in Cell Browser →

Mean expression uses the current overview’s precomputed gene means from the displayed 10,000-cell sample, matching the overview gene-ranking panel. These are not full-population means and are not IC scores. Every gene with a finite value is included, including zero expression.

Rows 21,001–22,000 of 28,231; ranked by score descending. Equal values use name/identifier order.

Gene expression ranked for MAC.MDM.complement_resolving
Browsers#GeneMean expressionMeta traits (High Priority)Individual traits (High Priority)
21001M1AP0.0000
21002MAATS10.00——
21003MAB21L10.0000
21004MAB21L20.0000
21005MAB21L30.0011
21006MACC10.0045
21007MACC1-AS10.0000
21008MACROD10.00819
21009MACROD20.0000
21010MACROD2-AS10.00——
21011MAD2L10.0022
21012MAEL0.0033
21013MAFA0.0085
21014MAFA-AS10.0096
21015MAFK0.0069
21016MAFTRR0.0000
21017MAG0.0011
21018MAGEA10.00——
21019MAGEA100.00——
21020MAGEA110.00——
21021MAGEA120.00——
21022MAGEA40.00——
21023MAGEA60.00——
21024MAGEA8-AS10.00——
21025MAGEA9B0.00——
21026MAGEB10.00——
21027MAGEB100.00——
21028MAGEB170.00——
21029MAGEB20.00——
21030MAGEB30.00——
21031MAGEC10.00——
21032MAGEC30.00——
21033MAGED10.00——
21034MAGED40.00——
21035MAGED4B0.00——
21036MAGEE10.00——
21037MAGEE20.00——
21038MAGEF10.0000
21039MAGEH10.00——
21040MAGEL20.00——
21041MAGI10.0011
21042MAGI1-AS10.00——
21043MAGI20.0044
21044MAGI2-AS10.00——
21045MAGI2-AS20.00——
21046MAGI30.0000
21047MAGIX0.00——
21048MAIP10.0011
21049MAJIN0.0000
21050MAK0.0033
21051MAK160.00314
21052MAL0.00——
21053MAL20.00610
21054MALL0.0000
21055MALRD10.0034
21056MALSU10.0025
21057MAMDC20.0049
21058MAMDC2-AS10.0026
21059MAMDC40.001422
21060MAML10.0056
21061MAMLD10.00——
21062MAMSTR0.00144185
21063MAN1A20.001220
21064MAN1B10.001947
21065MAN1C10.0034
21066MAN2A20.002034
21067MAN2B20.0001
21068MANBAL0.0000
21069MANEA0.0000
21070MANEAL0.0000
21071MANSC10.0024
21072MANSC40.0022
21073MAOA0.00——
21074MAOB0.00——
21075MAP100.0025
21076MAP1A0.0012
21077MAP1B0.0000
21078MAP1LC3A0.0000
21079MAP1LC3B20.0000
21080MAP1LC3C0.0000
21081MAP20.0011
21082MAP2K50.00623
21083MAP2K60.0022
21084MAP3K100.0011
21085MAP3K120.0032
21086MAP3K14-AS10.001835
21087MAP3K150.00——
21088MAP3K190.0000
21089MAP3K200.00820
21090MAP3K20-AS10.0011
21091MAP3K210.0000
21092MAP3K30.0021
21093MAP3K40.0050284
21094MAP3K50.0036
21095MAP3K60.00713
21096MAP3K70.0000
21097MAP3K7CL0.0023110
21098MAP3K90.0000
21099MAP40.0000
21100MAP4K20.0058
21101MAP4K40.0022
21102MAP4K50.0000
21103MAP60.0033
21104MAP6D10.0066
21105MAP70.0011
21106MAP7D20.00——
21107MAP7D30.00——
21108MAP90.001638
21109MAPK10.0011
21110MAPK100.001138
21111MAPK110.00815
21112MAPK120.001226
21113MAPK130.001016
21114MAPK140.002443
21115MAPK150.0044
21116MAPK30.001019
21117MAPK40.0000
21118MAPK70.0000
21119MAPK8IP10.0011
21120MAPK8IP20.0000
21121MAPK8IP30.001114
21122MAPK90.0011
21123MAPKAPK20.001920
21124MAPKBP10.001649
21125MAPRE30.001213
21126MAPT0.00152527
21127MARC10.00——
21128MARC20.00——
21129MARCH10.00——
21130MARCH100.00——
21131MARCH110.00——
21132MARCH20.00——
21133MARCH30.00——
21134MARCH40.00——
21135MARCH50.00——
21136MARCH60.00——
21137MARCH70.00——
21138MARCH80.00——
21139MARCH90.00——
21140MARCKSL10.0000
21141MARK10.0078
21142MARK20.0000
21143MARK40.002173
21144MARS0.00——
21145MARS20.00011
21146MARVELD10.0039
21147MARVELD20.0000
21148MARVELD30.0066135
21149MAS10.0046371
21150MASP10.001217
21151MASP20.001622
21152MAST10.0011
21153MAST20.001350
21154MAST30.0076182
21155MAST40.0037
21156MAST4-AS10.0026
21157MASTL0.0000
21158MAT1A0.002143
21159MATK0.0000
21160MATN10.00826
21161MATN1-AS10.00827
21162MATN20.00610
21163MATN30.001744
21164MATN40.0052123
21165MATR30.0000
21166MAU20.0061221
21167MAVS0.001031
21168MAZ0.0022
21169MB0.0034
21170MBD20.0010
21171MBD3L10.0000
21172MBIP0.0000
21173MBLAC10.0000
21174MBNL1-AS10.001027
21175MBOAT10.0010
21176MBOAT20.0000
21177MBOAT40.0000
21178MBOAT70.0062116
21179MBTD10.0000
21180MBTPS10.003680
21181MBTPS20.00——
21182MC1R0.001746
21183MC2R0.0000
21184MC3R0.00——
21185MC4R0.0000
21186MC5R0.0000
21187MCAM0.001324
21188MCAT0.001753
21189MCC0.00911
21190MCCC10.0011
21191MCCC1-AS10.00——
21192MCEE0.0000
21193MCF20.00——
21194MCF2L0.001561
21195MCF2L-AS10.00313
21196MCF2L20.0039
21197MCHR10.0000
21198MCHR20.0000
21199MCHR2-AS10.00——
21200MCIDAS0.00930
21201MCM100.0000
21202MCM20.00810
21203MCM30.0015
21204MCM3AP-AS10.003382
21205MCM50.0039
21206MCM60.00922
21207MCM70.0002
21208MCM80.0097
21209MCM8-AS10.0021
21210MCM90.0014
21211MCMBP0.00928
21212MCMDC20.0000
21213MCOLN20.0011
21214MCOLN30.0013
21215MCPH1-AS10.00632
21216MCTP20.0023
21217MCU0.0000
21218MCUR10.0033
21219MDC10.00155295
21220MDFI0.001354
21221MDFIC20.0000
21222MDGA10.0049
21223MDGA20.0011
21224MDH1B0.0011
21225MDK0.0057347
21226MDM10.0011
21227MDM20.0011
21228MDN10.0012
21229MDS20.0000
21230MECOM0.001456
21231MECR0.0000
21232MED10.00517
21233MED110.001335
21234MED120.00——
21235MED12L0.0000
21236MED130.0023
21237MED140.00——
21238MED14OS0.00——
21239MED170.0000
21240MED180.0011
21241MED210.0000
21242MED220.002942
21243MED230.0000
21244MED240.003335
21245MED260.00312
21246MED4-AS10.0011
21247MED70.001557
21248MEDAG0.0000
21249MEF2C-AS10.004167
21250MEF2C-AS20.0046
21251MEFV0.0033
21252MEG30.001343
21253MEG80.00722
21254MEG90.00722
21255MEGF100.0025
21256MEGF110.0000
21257MEGF60.0026
21258MEGF80.0000
21259MEI40.0000
21260MEIG10.0000
21261MEIKIN0.00726
21262MEIOB0.0033
21263MEIOC0.00828
21264MEIS10.0024
21265MEIS1-AS20.0000
21266MEIS1-AS30.0000
21267MEIS20.0000
21268MEIS30.001122
21269MELK0.0000
21270MELTF0.0001
21271MELTF-AS10.0000
21272MEOX10.0040209
21273MEOX20.00627
21274MEP1A0.0000
21275MEP1B0.0010
21276MEPE0.00924
21277MESP10.00819
21278MESP20.00920
21279MEST0.0035
21280MESTIT10.0000
21281MET0.0020135
21282METAP1D0.0011
21283METRN0.0001
21284METTL10.001941
21285METTL11B0.00——
21286METTL120.00——
21287METTL160.0014
21288METTL180.0022105
21289METTL21A0.0022
21290METTL21C0.0000
21291METTL240.0000
21292METTL260.00412
21293METTL270.003578
21294METTL2A0.00641
21295METTL2B0.00511
21296METTL30.0000
21297METTL40.0000
21298METTL7A0.00——
21299METTL7B0.00——
21300METTL80.0033
21301MEX3A0.001018
21302MEX3B0.0021
21303MEX3C0.0000
21304MEX3D0.0011
21305MFAP20.002565
21306MFAP30.0010
21307MFAP3L0.0000
21308MFAP40.0016
21309MFAP50.00——
21310MFGE80.001746
21311MFHAS10.0051225
21312MFN20.00712
21313MFSD120.0058
21314MFSD13A0.003644
21315MFSD14C0.00——
21316MFSD2B0.00434
21317MFSD30.0010
21318MFSD4A0.0033
21319MFSD4B0.0003
21320MFSD50.0000
21321MFSD60.0067
21322MFSD6L0.0022
21323MFSD90.00218
21324MGA0.00610
21325MGAM0.0000
21326MGAM20.0000
21327MGARP0.0023
21328MGAT30.0024
21329MGAT3-AS10.0024
21330MGAT4B0.001416
21331MGAT4C0.0000
21332MGAT4D0.00——
21333MGAT5B0.00——
21334MGC162750.0044
21335MGC328050.00510
21336MGEA50.00——
21337MGP0.0038
21338MGST10.0021
21339MHENCR0.003681
21340MIA0.001018
21341MIA-RAB4B0.004182
21342MIAT0.0011
21343MIATNB0.0032
21344MIB10.00——
21345MICAL20.0015
21346MICAL30.002127
21347MICALL10.0013
21348MICALL20.00612
21349MICU30.0035
21350MID10.00——
21351MID1IP10.00——
21352MID1IP1-AS10.00——
21353MID20.00——
21354MIEF10.0024
21355MIEF20.0000
21356MIER20.0011
21357MIER30.0022
21358MIF-AS10.00——
21359MIGA20.00511
21360MIIP0.001425
21361MIMT10.0000
21362MINCR0.002669
21363MINDY20.002647
21364MINDY30.0015
21365MINDY40.0028
21366MINOS10.00——
21367MINPP10.00920
21368MIOX0.0000
21369MIP0.0002
21370MIPEP0.0011
21371MIPOL10.00612
21372MIR1-1HG0.0000
21373MIR124-2HG0.0000
21374MIR133A1HG0.00——
21375MIR137HG0.0047
21376MIR181A2HG0.0057
21377MIR193BHG0.0017
21378MIR194-2HG0.0010
21379MIR200CHG0.0000
21380MIR202HG0.0034
21381MIR2052HG0.0000
21382MIR210HG0.001123
21383MIR2117HG0.001020
21384MIR217HG0.00516
21385MIR222HG0.00——
21386MIR3142HG0.0011
21387MIR34AHG0.001121
21388MIR3663HG0.0011
21389MIR3681HG0.0022
21390MIR381HG0.00——
21391MIR3945HG0.001229
21392MIR3976HG0.0000
21393MIR4290HG0.00——
21394MIR4300HG0.0000
21395MIR4422HG0.0000
21396MIR4432HG0.0039
21397MIR4458HG0.0000
21398MIR4500HG0.0000
21399MIR4527HG0.0000
21400MIR4713HG0.0000
21401MIR497HG0.002139
21402MIR548XHG0.00——
21403MIR5689HG0.00——
21404MIR583HG0.00——
21405MIR646HG0.0000
21406MIR7-3HG0.0034
21407MIR7515HG0.00——
21408MIR762HG0.0000
21409MIR9-3HG0.0000
21410MIR99AHG0.0039
21411MIRLET7BHG0.0053
21412MIS18A-AS10.0000
21413MISP0.002349
21414MISP30.001540
21415MIXL10.0000
21416MKI670.0000
21417MKL10.00——
21418MKL20.00——
21419MKNK1-AS10.0000
21420MKRN20.0014
21421MKRN2OS0.0014
21422MKRN30.0000
21423MKS10.0002
21424MKX0.0011
21425MKX-AS10.0011
21426MLANA0.0022
21427MLC10.00316
21428MLEC0.001117
21429MLF10.00411
21430MLH10.0013
21431MLH30.0011
21432MLIP0.00412
21433MLIP-AS10.0000
21434MLLT10.0011
21435MLLT110.001142
21436MLLT60.0002
21437MLN0.0000
21438MLPH0.001429
21439MLX0.0039147
21440MLXIP0.003667
21441MLXIPL0.002331,124
21442MMAA0.0023
21443MMACHC0.0011
21444MMD20.0000
21445MME0.0022
21446MME-AS10.0000
21447MMEL10.0026
21448MMP10.0033
21449MMP100.0033
21450MMP110.0000
21451MMP120.0022
21452MMP130.0000
21453MMP140.002853
21454MMP150.0027
21455MMP160.0000
21456MMP170.0048
21457MMP20.0046
21458MMP200.0001
21459MMP210.0011
21460MMP23B0.00214
21461MMP240.0000
21462MMP250.0039
21463MMP25-AS10.0000
21464MMP260.0000
21465MMP270.0044
21466MMP280.0044
21467MMP30.0000
21468MMP70.0049
21469MMP80.0044
21470MMRN10.0035
21471MMRN20.0034
21472MMS190.001144
21473MMS22L0.0000
21474MN10.0047
21475MND10.0013
21476MNS10.0000
21477MNT0.0089
21478MNX10.0022
21479MNX1-AS10.0022
21480MNX1-AS20.0022
21481MOAP10.0000
21482MOB20.001427
21483MOBP0.0017
21484MOCOS0.0000
21485MOCS10.0032
21486MOCS20.001117
21487MOCS30.0000
21488MOG0.0068
21489MOGAT10.0000
21490MOGAT20.002354
21491MOGAT30.002444
21492MOGS0.0000
21493MOK0.0022
21494MON1A0.005099
21495MON1B0.0000
21496MON20.0012
21497MORC10.0000
21498MORC1-AS10.00——
21499MORC20.001142
21500MORC2-AS10.001039
21501MORC40.00——
21502MORN10.001054
21503MORN30.001437
21504MORN40.0022
21505MORN50.0000
21506MOSPD30.002894
21507MOV100.0032115
21508MOV10L10.00718
21509MOXD10.00721
21510MPDZ0.0022
21511MPEG10.0012
21512MPHOSPH100.0000
21513MPHOSPH90.0012
21514MPI0.0036
21515MPIG6B0.00115
21516MPL0.001028
21517MPND0.00818
21518MPO0.001750
21519MPP20.00411
21520MPP30.0040214
21521MPP40.0000
21522MPP50.00——
21523MPP60.00——
21524MPP70.0011
21525MPPED10.0022
21526MPPED20.0011
21527MPRIP0.00525
21528MPRIP-AS10.00——
21529MPST0.00838
21530MPV170.00274641
21531MPV17L0.0026
21532MPV17L20.001225
21533MPZ0.001116
21534MPZL10.0011
21535MPZL20.001964
21536MPZL30.001659
21537MR10.0011
21538MRAP0.0000
21539MRAP20.0000
21540MRAS0.001129
21541MRC20.001464
21542MREG0.0012
21543MRFAP1L10.0011
21544MRGBP0.0000
21545MRGPRE0.0000
21546MRGPRF0.003497
21547MRGPRF-AS10.001758
21548MRGPRX20.0000
21549MRGPRX30.0000
21550MRGPRX40.0000
21551MRI10.00317
21552MRLN0.0000
21553MRM10.00815
21554MRM30.0012
21555MRO0.0010
21556MROH2A0.003142
21557MROH2B0.0014
21558MROH60.001237
21559MROH70.00830
21560MROH7-TTC40.00830
21561MROH80.0000
21562MROH90.0013
21563MRPL170.0000
21564MRPL210.001148
21565MRPL220.0000
21566MRPL23-AS10.001134
21567MRPL240.0001
21568MRPL350.0000
21569MRPL370.001036
21570MRPL420.001137
21571MRPL440.0044
21572MRPL480.0022
21573MRPL490.0034
21574MRPL90.0000
21575MRPS110.0023
21576MRPS140.00616
21577MRPS220.0000
21578MRPS230.0011
21579MRPS270.0000
21580MRPS300.00——
21581MRPS360.00——
21582MRRF0.0000
21583MRS20.00728
21584MRTO40.001024
21585MRVI10.00——
21586MRVI1-AS10.00——
21587MS4A10.0079120
21588MS4A100.0011
21589MS4A120.0056
21590MS4A130.0095152
21591MS4A150.001764
21592MS4A180.0000
21593MS4A20.003466
21594MS4A30.003365
21595MS4A50.006999
21596MS4A6E0.0077122
21597MS4A80.004762
21598MSANTD10.004086
21599MSANTD20.0000
21600MSANTD30.0010
21601MSANTD3-TMEFF10.0000
21602MSANTD40.0000
21603MSC-AS10.0000
21604MSGN10.0001
21605MSH20.0000
21606MSH30.0000
21607MSH40.0000
21608MSH50.00714
21609MSH5-SAPCD10.00713
21610MSH60.00510
21611MSI10.0000
21612MSL10.001513
21613MSL20.001229
21614MSLN0.0011
21615MSLNL0.00——
21616MSMB0.0015
21617MSMO10.0011
21618MSMP0.001646
21619MSRB30.0000
21620MSS510.0000
21621MST10.0067154
21622MST1R0.0051102
21623MSTN0.0000
21624MSTO10.00823
21625MSX10.0000
21626MSX20.0000
21627MT1A0.0027116
21628MT1B0.0000
21629MT1E0.002037
21630MT1F0.0002
21631MT1G0.0028174
21632MT1H0.0036222
21633MT1HL10.00——
21634MT1M0.002970
21635MT30.0014
21636MT40.0002
21637MTBP0.0000
21638MTCL10.0013
21639MTERF10.0000
21640MTERF20.0033
21641MTERF30.0000
21642MTF10.0011
21643MTFR10.0034
21644MTFR20.0000
21645MTG20.00824
21646MTHFD10.0059
21647MTHFD1L0.0001
21648MTHFD2L0.001240
21649MTHFR0.0037105
21650MTHFS0.001238
21651MTHFSD0.00412
21652MTIF20.0000
21653MTM10.00——
21654MTMR10.00——
21655MTMR100.00214
21656MTMR110.0056158
21657MTMR120.0000
21658MTMR20.00816
21659MTMR30.00715
21660MTMR40.00911
21661MTMR70.001739
21662MTMR80.00——
21663MTMR90.002135
21664MTNR1A0.00312
21665MTNR1B0.0000
21666MTOR-AS10.0000
21667MTPAP0.0047
21668MTRF1L0.0001
21669MTRNR2L10.00——
21670MTRNR2L100.00——
21671MTRNR2L110.00——
21672MTRNR2L120.00——
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21674MTRNR2L30.00——
21675MTRNR2L40.00——
21676MTRNR2L50.00——
21677MTRNR2L60.00——
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21965NEURL1B0.00412
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21982NFATC30.001774
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22000NGF0.0012