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Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

MAC.MDM.complement_resolving: Gene expression — page 19

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links
Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant
The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1)
Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2)
Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values
CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits
Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links
Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support
The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support
The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority
Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority
Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation
Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation
A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

State · 1,931 full-atlas cells · all tissues.

Marker genes and cell annotation · Open this population in Cell Browser →

Mean expression uses the current overview’s precomputed gene means from the displayed 10,000-cell sample, matching the overview gene-ranking panel. These are not full-population means and are not IC scores. Every gene with a finite value is included, including zero expression.

Rows 18,001–19,000 of 28,231; ranked by score descending. Equal values use name/identifier order.

Gene expression ranked for MAC.MDM.complement_resolving
Browsers#GeneMean expressionMeta traits (High Priority)Individual traits (High Priority)
18001HRNR0.00——
18002HS1BP30.00851,001
18003HS3ST10.0012
18004HS3ST20.00——
18005HS3ST3A10.00210
18006HS3ST3B10.00514
18007HS3ST40.0000
18008HS3ST50.0000
18009HS3ST60.0001
18010HS6ST10.0000
18011HS6ST20.00——
18012HS6ST2-AS10.00——
18013HS6ST30.0047
18014HSD11B10.001646
18015HSD11B1L0.0000
18016HSD11B20.002469
18017HSD17B10.0011
18018HSD17B130.0083324
18019HSD17B140.001618
18020HSD17B20.0000
18021HSD17B30.0011
18022HSD17B3-AS10.0022
18023HSD17B60.0022280
18024HSD17B80.0038
18025HSD3B10.0011
18026HSD3B20.0011
18027HSD3B70.0046104
18028HSDL10.003781
18029HSF10.0000
18030HSF20.0027
18031HSF2BP0.0000
18032HSF40.001424
18033HSF50.00413
18034HSFX10.00——
18035HSFY10.00——
18036HSFY20.00——
18037HSH2D0.00412
18038HSPA12A0.001313
18039HSPA12B0.002345
18040HSPA130.001222
18041HSPA140.0034
18042HSPA1L0.0001
18043HSPA20.0000
18044HSPA4L0.0000
18045HSPB110.00——
18046HSPB30.0000
18047HSPB60.00110
18048HSPB70.002977
18049HSPB80.0000
18050HSPB90.00920
18051HSPBP10.0020
18052HSPG20.004792
18053HTATSF10.00——
18054HTN10.0000
18055HTN30.0000
18056HTR1A0.00——
18057HTR1B0.0010
18058HTR1D0.00723
18059HTR1E0.00——
18060HTR1F0.0001
18061HTR2A0.00——
18062HTR2A-AS10.00——
18063HTR2B0.00913
18064HTR2C0.00——
18065HTR3A0.0089
18066HTR3B0.0022
18067HTR3C0.0024
18068HTR3D0.00——
18069HTR3E0.0023
18070HTR3E-AS10.00——
18071HTR40.0000
18072HTR5A0.0033
18073HTR5A-AS10.0010
18074HTR60.00922
18075HTR70.0003
18076HTRA10.002146
18077HTRA30.00412
18078HTT-AS0.002247
18079HUNK0.0000
18080HUNK-AS10.0000
18081HUS1B0.00919
18082HYAL10.002251
18083HYAL20.00512
18084HYAL40.0000
18085HYDIN0.001214
18086HYKK0.0035
18087HYLS10.0022
18088IAPP0.0089
18089IARS0.00——
18090IBA570.0000
18091IBSP0.00716
18092ICA10.0000
18093ICA1L0.0011
18094ICAM30.002848
18095ICAM50.00612
18096ICK0.00——
18097ICMT0.006165
18098ICOS0.0002
18099ICOSLG0.00514
18100ID40.00617
18101IDE0.0000
18102IDH10.0036
18103IDH1-AS10.0000
18104IDI10.0065
18105IDI20.00613
18106IDI2-AS10.00714
18107IDO10.0000
18108IDO20.0000
18109IDUA0.002052
18110IER50.00520
18111IFFO20.0013
18112IFIT1B0.0033
18113IFIT50.0044
18114IFITM100.0038
18115IFNA10.00——
18116IFNA130.00——
18117IFNA20.0000
18118IFNA40.00——
18119IFNA50.00——
18120IFNA60.00——
18121IFNB10.0000
18122IFNE0.0000
18123IFNG0.0000
18124IFNG-AS10.0000
18125IFNK0.0025
18126IFNL10.0011
18127IFNLR10.0045
18128IFRD20.00920
18129IFT1220.0022
18130IFT1400.002452
18131IFT1720.005751,693
18132IFT220.001524
18133IFT430.0000
18134IFT460.001941
18135IFT740.0022
18136IFT74-AS10.0000
18137IFT810.00522
18138IGBP10.00——
18139IGBP1-AS10.00——
18140IGBP1-AS20.00——
18141IGDCC30.0011
18142IGDCC40.0011
18143IGF1R0.0025
18144IGF20.0043132
18145IGF2-AS0.0040125
18146IGF2BP10.00613
18147IGF2BP20.00611
18148IGF2BP2-AS10.0047
18149IGF2BP30.0011
18150IGF2R0.001411,020
18151IGFALS0.001213
18152IGFBP10.00814
18153IGFBP20.00812
18154IGFBP30.001793
18155IGFBP50.00611
18156IGFBP60.0022
18157IGFBP7-AS10.002047
18158IGFBPL10.0011
18159IGFL10.0000
18160IGFL20.0000
18161IGFL2-AS10.0000
18162IGFL30.0000
18163IGFL40.0000
18164IGFN10.0000
18165IGHA10.0079
18166IGHA20.0000
18167IGHD0.0000
18168IGHE0.0011
18169IGHEP20.00——
18170IGHG10.001414
18171IGHG20.0021
18172IGHG30.001415
18173IGHG40.0000
18174IGHGP0.0000
18175IGHM0.0000
18176IGHV1-180.0000
18177IGHV1-20.0000
18178IGHV1-240.0000
18179IGHV1-30.0000
18180IGHV1-460.0000
18181IGHV1-690.0011
18182IGHV1OR15-10.00——
18183IGHV1OR15-60.00——
18184IGHV1OR15-90.00——
18185IGHV1OR16-40.00——
18186IGHV2-260.0000
18187IGHV2-50.0011
18188IGHV2-700.0000
18189IGHV3-110.0000
18190IGHV3-130.0000
18191IGHV3-150.0000
18192IGHV3-200.0000
18193IGHV3-210.0000
18194IGHV3-230.0000
18195IGHV3-300.0037118
18196IGHV3-320.00——
18197IGHV3-330.0000
18198IGHV3-480.0000
18199IGHV3-490.0000
18200IGHV3-530.0000
18201IGHV3-660.0000
18202IGHV3-70.0000
18203IGHV3-720.0000
18204IGHV3-730.0000
18205IGHV3-740.0000
18206IGHV3OR15-70.00——
18207IGHV3OR16-120.00——
18208IGHV3OR16-130.0078
18209IGHV3OR16-150.00——
18210IGHV4-280.0000
18211IGHV4-310.0000
18212IGHV4-340.0000
18213IGHV4-390.0000
18214IGHV4-590.0000
18215IGHV4-610.0000
18216IGHV4OR15-80.00——
18217IGHV5-510.0000
18218IGHV6-10.0000
18219IGIP0.00710
18220IGKC0.0000
18221IGKV1-120.0000
18222IGKV1-130.00——
18223IGKV1-160.0000
18224IGKV1-170.0000
18225IGKV1-270.0000
18226IGKV1-330.00——
18227IGKV1-390.00——
18228IGKV1-50.0000
18229IGKV1-60.0000
18230IGKV1-80.00——
18231IGKV1-90.0000
18232IGKV1D-120.0000
18233IGKV1D-130.0000
18234IGKV1D-160.0010
18235IGKV1D-170.00——
18236IGKV1D-270.00——
18237IGKV1D-330.0011
18238IGKV1D-370.0000
18239IGKV1D-390.00——
18240IGKV1D-430.00——
18241IGKV1D-80.00——
18242IGKV1OR2-1080.001133
18243IGKV1OR2-60.00——
18244IGKV1OR22-10.00——
18245IGKV2-180.00——
18246IGKV2-240.0000
18247IGKV2-260.00——
18248IGKV2-280.0000
18249IGKV2-290.00——
18250IGKV2-300.0000
18251IGKV2D-180.00——
18252IGKV2D-260.00——
18253IGKV2D-280.00——
18254IGKV2D-290.00——
18255IGKV2D-300.00——
18256IGKV2D-400.00——
18257IGKV2OR22-30.00——
18258IGKV2OR22-40.00——
18259IGKV3-110.0000
18260IGKV3-150.0000
18261IGKV3-200.0000
18262IGKV3-70.0000
18263IGKV3D-110.00——
18264IGKV3D-150.00——
18265IGKV3D-200.00——
18266IGKV4-10.0000
18267IGKV5-20.0000
18268IGKV6-210.00——
18269IGKV6D-210.00——
18270IGKV6D-410.00——
18271IGKV7-30.00——
18272IGLC20.0000
18273IGLC30.0011
18274IGLC50.00——
18275IGLC60.00——
18276IGLC70.0000
18277IGLCOR22-20.00——
18278IGLL10.0000
18279IGLL50.0000
18280IGLON50.00615
18281IGLV1-360.0000
18282IGLV1-400.0000
18283IGLV1-410.00——
18284IGLV1-440.0000
18285IGLV1-470.0000
18286IGLV1-500.0000
18287IGLV1-510.0000
18288IGLV10-540.0000
18289IGLV11-550.0000
18290IGLV2-110.0000
18291IGLV2-140.0056
18292IGLV2-180.0000
18293IGLV2-230.0000
18294IGLV2-80.0000
18295IGLV3-10.0000
18296IGLV3-100.0000
18297IGLV3-120.0000
18298IGLV3-160.0011
18299IGLV3-190.0034
18300IGLV3-210.00——
18301IGLV3-220.0000
18302IGLV3-240.00——
18303IGLV3-250.0000
18304IGLV3-270.0000
18305IGLV3-60.00——
18306IGLV3-90.0000
18307IGLV4-600.0000
18308IGLV4-690.0000
18309IGLV5-370.0000
18310IGLV5-450.0000
18311IGLV5-480.0000
18312IGLV5-520.0000
18313IGLV6-570.0000
18314IGLV7-430.0012
18315IGLV7-460.0000
18316IGLV8-610.0000
18317IGLV9-490.0000
18318IGLVI-700.00——
18319IGLVIVOR22-10.00——
18320IGSF10.00——
18321IGSF100.00311
18322IGSF110.0000
18323IGSF11-AS10.00——
18324IGSF220.0011
18325IGSF230.0077688
18326IGSF30.0035
18327IGSF50.0011
18328IGSF90.001114
18329IGSF9B0.0035
18330IHH0.00212
18331IKBKE0.001434
18332IKBKG0.00——
18333IKZF20.00927
18334IKZF30.0083204
18335IKZF40.0000
18336IL110.00310
18337IL11RA0.0000
18338IL12A0.0022
18339IL12A-AS10.0000
18340IL12B0.0022
18341IL12RB20.0022
18342IL130.0000
18343IL13RA20.00——
18344IL15RA0.0000
18345IL17A0.0000
18346IL17B0.0000
18347IL17C0.002764
18348IL17D0.00245
18349IL17F0.0000
18350IL17RB0.001428
18351IL17RC0.0011
18352IL17RD0.001216
18353IL17RE0.0022
18354IL17REL0.001213
18355IL18R10.0052145
18356IL18RAP0.0048140
18357IL190.001617
18358IL1A0.00622
18359IL1F100.001336
18360IL1R10.002448
18361IL1RAP0.0021
18362IL1RAPL10.00——
18363IL1RAPL20.00——
18364IL1RL10.0043110
18365IL1RL20.003879
18366IL20.0022
18367IL200.001211
18368IL20RA0.0046
18369IL20RB0.002045
18370IL20RB-AS10.0058
18371IL210.0011
18372IL21-AS10.0011
18373IL21R0.001327
18374IL21R-AS10.00——
18375IL220.0000
18376IL22RA10.0011
18377IL22RA20.0049
18378IL23A0.0001
18379IL23R0.0022
18380IL240.001313
18381IL250.00338
18382IL260.0000
18383IL270.002954
18384IL2RA0.00920
18385IL2RB0.001552
18386IL30.00929
18387IL310.00——
18388IL31RA0.00914
18389IL320.0035
18390IL330.0012
18391IL340.0031
18392IL36A0.001541
18393IL36B0.001743
18394IL36G0.001847
18395IL36RN0.001644
18396IL370.00518
18397IL3RA0.00——
18398IL40.005493
18399IL4R0.00947
18400IL50.00128192
18401IL5RA0.0017
18402IL60.001338
18403IL6R0.0065111
18404IL70.0000
18405IL7R0.002476
18406IL90.00——
18407IL9R0.00——
18408ILDR10.001543
18409ILDR20.0033
18410ILVBL0.0011
18411IMMP1L0.0000
18412IMMP2L0.0000
18413IMPA20.00613
18414IMPAD10.00——
18415IMPG10.0000
18416IMPG20.0022
18417INA0.001429
18418INAFM10.0027
18419INAFM20.00820
18420INAVA0.0022
18421INCA10.0035
18422INCENP0.0011
18423INE20.00——
18424ING10.0000
18425ING50.0000
18426INHA0.0035
18427INHBA-AS10.0000
18428INHBB0.00620
18429INHBC0.002753
18430INHBE0.0040200
18431INMT0.0025
18432INMT-MINDY40.00612
18433INO80-AS10.0066
18434INO80B0.0000
18435INO80B-WBP10.0000
18436INO80C0.0000
18437INO80D0.0038
18438INPP4A0.0011
18439INPP4B0.0011
18440INPP5A0.00414
18441INPP5F0.001742
18442INPP5J0.001240
18443INPP5K0.0055122
18444INS-IGF20.0036121
18445INSC0.0000
18446INSL30.0046
18447INSL40.0010
18448INSL50.0001
18449INSL60.0010
18450INSM10.0000
18451INSM20.0000
18452INSR0.0047170
18453INSRR0.0022
18454INTS120.0000
18455INTS140.0000
18456INTS20.0000
18457INTS30.0089
18458INTS50.0011
18459INTS60.0000
18460INTS6-AS10.0000
18461INTS6L0.00——
18462INTS70.001333
18463INTS80.00420
18464INTS90.0000
18465INTS9-AS10.00——
18466INTU0.0000
18467INVS0.0011
18468IP6K10.0000
18469IP6K30.00725
18470IPCEF10.0011
18471IPO110.0000
18472IPO130.0024
18473IPO40.0057
18474IPO50.001933
18475IPO80.0011
18476IPO90.00931
18477IPP0.0000
18478IPPK0.0069
18479IQANK10.0058
18480IQCA10.0011
18481IQCA1-AS10.00——
18482IQCA1L0.0000
18483IQCC0.0011
18484IQCD0.00711
18485IQCE0.001128
18486IQCF10.00——
18487IQCF20.00——
18488IQCF30.00——
18489IQCF50.00——
18490IQCH0.001131
18491IQCH-AS10.0033
18492IQCJ-SCHIP10.0034
18493IQCJ-SCHIP1-AS10.00——
18494IQCK0.0000
18495IQCM0.0000
18496IQGAP30.0034104
18497IQSEC20.00——
18498IQSEC30.0000
18499IQUB0.0000
18500IRAK10.00——
18501IRAK1BP10.00213
18502IREB20.0035
18503IRF2BP10.0080281
18504IRF2BPL0.0034
18505IRF40.003794
18506IRF60.001236
18507IRGC0.00——
18508IRGM0.00813
18509IRGQ0.003055
18510IRS10.0069
18511IRS20.001764
18512IRS40.00——
18513IRX10.0000
18514IRX20.0000
18515IRX30.0000
18516IRX40.0025
18517IRX50.0000
18518IRX60.0024
18519ISL10.00——
18520ISL20.0000
18521ISLR0.002862
18522ISLR20.003068
18523ISM10.0000
18524ISM1-AS10.00——
18525ISM20.0000
18526ISPD0.00——
18527ISPD-AS10.00——
18528ISX0.0000
18529ISYNA10.0057136
18530ITCH-AS10.00——
18531ITFG1-AS10.0011
18532ITFG20.0000
18533ITGA10.002440
18534ITGA100.00——
18535ITGA110.0012
18536ITGA20.002440
18537ITGA2B0.0043
18538ITGA30.0014
18539ITGA50.00313
18540ITGA60.0045
18541ITGA70.0005
18542ITGA80.0015
18543ITGA90.0045
18544ITGAD0.001936
18545ITGB1BP20.00——
18546ITGB30.001538
18547ITGB40.002863
18548ITGB50.002843
18549ITGB5-AS10.002226
18550ITGB60.00821
18551ITGB70.0037
18552ITGB80.0043
18553ITGBL10.0010
18554ITIH10.00124481
18555ITIH20.0022
18556ITIH30.0095457
18557ITIH40.00121499
18558ITIH4-AS10.00——
18559ITIH50.0044
18560ITIH60.00——
18561ITK0.001859
18562ITLN10.003154
18563ITLN20.003154
18564ITM2A0.00——
18565ITM2C0.0000
18566ITPK1-AS10.00——
18567ITPKA0.0027
18568ITPKB0.0049
18569ITPKB-AS10.0023
18570ITPKC0.003061
18571ITPR10.002154
18572ITPR30.00932
18573ITPRIPL10.00——
18574ITPRIPL20.0000
18575IVL0.0000
18576IYD0.0047
18577IZUMO10.0097104
18578IZUMO1R0.0000
18579IZUMO20.0001
18580IZUMO30.00——
18581IZUMO40.00726
18582JADE10.0000
18583JADE30.00——
18584JAG10.0040158
18585JAG20.0011
18586JAK20.001540
18587JAK30.0068
18588JAKMIP10.00320
18589JAKMIP20.0011
18590JAKMIP2-AS10.0011
18591JAKMIP30.0011
18592JAM20.0023
18593JAM30.0025
18594JARID2-AS10.00525
18595JAZF1-AS10.0000
18596JCAD0.001256
18597JCHAIN0.0016
18598JDP20.00412
18599JMJD1C-AS10.001319
18600JMJD80.0000
18601JMY0.002780
18602JPH10.0033
18603JPH20.001347
18604JPH30.0011
18605JPH40.006104
18606JRK0.00812
18607JRKL0.0010
18608JRKL-AS10.0000
18609JSRP10.001124
18610KAAG10.00——
18611KALRN0.002838
18612KANK10.001354
18613KANK20.00127940
18614KANK30.0065460
18615KANK40.0022
18616KANSL20.0010
18617KANSL30.00——
18618KANTR0.00——
18619KARS0.00——
18620KAT140.001852
18621KAT2B0.0000
18622KAT6A0.0000
18623KAT6B0.0000
18624KAT70.00311
18625KATNAL10.00215
18626KATNAL20.0000
18627KATNB10.0042
18628KAZALD10.0057
18629KAZN0.00210
18630KBTBD110.0022
18631KBTBD11-OT10.0001
18632KBTBD120.00911
18633KBTBD20.0069
18634KBTBD30.0011
18635KBTBD40.00——
18636KBTBD60.0015
18637KBTBD80.0000
18638KC60.0000
18639KC877392.10.00——
18640KCNA10.0000
18641KCNA20.0055
18642KCNA30.0022
18643KCNA40.0000
18644KCNA50.0000
18645KCNA70.003149
18646KCNAB1-AS10.00——
18647KCNAB1-AS20.0034
18648KCNAB30.001832
18649KCNB10.0011
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