Cell state · L2

T.MAIT.cytotoxic

1,155 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

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Marker genes

CCL4, CRIP1, GNLY, GZMB, GZMH, HLA-DPA1, HLA-DRB1, HLA-DRB5, KLRD1, KLRK1, LMNA, METRNL, MYADM, RGCC

Annotation genes

GNLY, GZMB, HLA-DRB1, KLRD1, KLRK1

Annotation rationales

GZMB/GZMH/GNLY establish robust cytotoxicity; KLRD1/KLRK1 add NK-like recognition; HLA-DRB1 upregulation signals IFN-γ–licensed APC-like activation; CCL4 aids recruitment. The set (GNLY, GZMB, HLA-DRB1, KLRD1, KLRK1) is classic MAIT1 effector.

Functional implications

Kill bacterially infected cells (MR1 ligands) and amplify local immunity by antigen/context presentation and chemokine orchestration in mucosa/liver.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.