Cell state · L2
T.CD8_naive.baseline
8,486 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CCR7, IL7R, KLF2, LEF1, LTB, SELL, TCF7
Annotation genes
CCR7, IL7R, KLF2, LEF1, LTB, SELL, TCF7
Annotation rationales
CCR7/SELL guide LN homing and entry; IL7R supports tonic survival; TCF7/LEF1 establish stem-like chromatin and rapid proliferation after priming; KLF2 maintains quiescence and S1P axis; LTB contributes to lymphoid microarchitecture. Together (CCR7, IL7R, KLF2, LEF1, LTB, SELL, TCF7) define the canonical resting CD8⁺ naïve scaffold primed for high-fidelity priming.
Functional implications
Sustain a long-lived, quiescent repertoire with rapid clonal expansion potential and full cytolytic differentiation upon antigen encounter in LNs.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.