Cell state · L2
T.CD4_transitional.primed_helper_effector
1,376 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD27, CORO1B, CTLA4, CXCL13, DNPH1, DRAIC, ICOS, ITM2A, KLRB1, LIMS1, PDCD1, PTTG1, SIRPG, SPOCK2, TBC1D4, TIGIT, TOX2
Annotation genes
CTLA4, CXCL13, ICOS, KLRB1, PDCD1, TIGIT
Annotation rationales
High KLRB1 with multiple checkpoints (TIGIT/PDCD1/CTLA4) and B-cell interface (ICOS, CXCL13) indicates activation with IL-7 withdrawal—a trajectory out of Tcm toward tissue engagement/Trm.
Functional implications
Helper/regulatory effector that lodges in tissues, provides B-cell help, and transitions to Tem/Trm; checkpoint-rich profile prevents runaway inflammation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.