Cell state · L2
T.CD4_Treg.tissue_effector
970 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
BATF, CTLA4, CXCR6, DUSP2, IL1R2, NAMPT, TNFRSF18, TNFRSF4, TNFRSF9
Annotation genes
CTLA4, CXCR6, TNFRSF18, TNFRSF4
Annotation rationales
CTLA4 with TNFRSF18/4/9 defines activated eTreg; CXCR6 supports inflamed-tissue retention; IL1R2 quenches IL-1; NAMPT reflects metabolic rewiring.
Functional implications
Dominant local suppression: strip CD80/86 from APCs, soak IL-2, restrain Th1/Th17, and guide to inflamed foci (CXCR6) to promote resolution and repair.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.