Cell state · L2
T.CD4_Treg.Tr1_like
451 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
FCMR, FOXP1, GIMAP4, GPR25, KLRB1, MAF, NOSIP, POU2AF1, S1PR4, UCP2
Annotation genes
KLRB1, MAF, S1PR4
Annotation rationales
KLRB1 (CD161) with MAF is characteristic of Tr1-like tolerance (often FOXP3-low); S1PR4 tunes blood-lymph transit; UCP2 (in markers) supports metabolic anergy.
Functional implications
Cytokine-mediated suppression (high IL-10 potential) with agile trafficking; quickly enter inflamed tissues to reinforce tolerance without heavy CTLA4 dependence.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.