Cell state · L2
T.CD4_Treg.APC_interactive
3,777 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCR10, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, LGALS1, LSP1, PI16, S100A11, TGFB1
Annotation genes
CCR10, TGFB1
Annotation rationales
HLA-II elevation in human Tregs supports direct APC crosstalk; CCR10 confers barrier homing; TGFB1 and LGALS1 contribute to a tolerogenic secretome that conditions local APCs.
Functional implications
Gatekeep priming and enforce mucosal tolerance: dampen costimulation, deliver TGF-β/galectin signals, and steer trafficking to epithelia (CCR10) to pre-empt inflammation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.