Cell state · L2
T.CD4_Tem.cytotoxic_effector
3,194 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCL4, CCL5, CD74, CRTAM, CST7, CTSW, EOMES, GZMK, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRB1, KLRD1, KLRK1, NKG7, PLEK, PRF1, TNFSF9, ZEB2
Annotation genes
CTSW, EOMES, GZMK, NKG7, PRF1
Annotation rationales
EOMES/ZEB2 (in markers) drive cytotoxic maturation; PRF1/NKG7/CTSW/GZMK deliver lysis; CRTAM aids tissue retention and synapse quality; CCL4/5 recruit effectors; inducible HLA-II/CD74 suggests heightened antigen scanning. The quintet (CTSW, EOMES, GZMK, NKG7, PRF1) centers the lytic arm.
Functional implications
Provide direct cytolysis and Th1 chemokine output in tissues, complementing helper roles; key for antiviral control and tumor surveillance in peripheral sites.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.