Cell state · L2
PC.IgG_systemic.interacting
478 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BTG2, DUSP2, EGR1, FOS, FOSB, GADD45B, IER3, JUN, JUNB, NFKBIA, PPP1R15A, TECR, UBB, ZFP36
Annotation genes
DUSP2, FOS, JUN, NFKBIA, ZFP36
Annotation rationales
FOS/JUN (AP-1) initiate rapid transcription after stimulation, while DUSP2 restrains MAPK signaling to prevent uncontrolled activation. NFKBIA provides NF-κB negative feedback, and ZFP36 accelerates decay of inflammatory transcripts, focusing resources on immunoglobulin production. Together, these genes reflect a plasmablast-like state responding acutely to antigenic or alarmin signals at mucosal sites.
Functional implications
Immediately after stimulation, these cells mount a high-output IgA secretion program to reinforce mucosal surfaces against pathogens, while also releasing cytokines and chemokines that recruit neutrophils and dendritic cells. By integrating stress brakes (DUSP2, NFKBIA) with transcriptional accelerators (FOS/JUN), they ensure a sharp but self-limiting wave of effector activity. Functionally, they protect mucosal barriers during acute infections or allergen encounters without driving chronic inflammation that would disrupt epithelial integrity.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.