Cell state · L2
PC.IgA_muocsal.migratory
6,276 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ARGLU1, CD38, CLMN, DDX17, DLC1, LINC-PINT, MUC3A, NEAT1, NR2F2-AS1, PDE7B, PDGFRB, RGL3, RIPOR3, SLC16A12, SOX5, TNS2, ZBTB20, ZRANB2
Annotation genes
DLC1, NR2F2-AS1, PDGFRB
Annotation rationales
The annotation genes indicate a pericyte subtype optimized for high-demand, contractile organs. PDGFRB again confirms lineage and growth-factor responsiveness to endothelial PDGF-B. DLC1 (RhoGAP) restrains RhoA signaling at focal adhesions to calibrate traction and vessel wall tension—critical in pulsatile myocardium and exercising skeletal muscle. NR2F2-AS1 points to the NR2F2/COUP-TFII regulatory axis that patterns venous/ microvascular identity and metabolic coupling. Together with cytoskeletal/adhesion scaffolds (e.g., TNS2 in markers), this profile supports robust mechano-adaptation and PDGF-driven remodeling in heart and skeletal muscle beds.
Functional implications
Stabilizes capillaries exposed to cyclic strain, rapidly adapting perivascular tension to match beat-to-beat (heart) or contraction-to-contraction (muscle) demands. Coordinates endothelial alignment and basement-membrane turnover during angiogenesis or collateralization, safeguarding perfusion and facilitating substrate delivery/clearance in metabolically intense tissues via PDGFRB and DLC1-tuned cytoskeletal control.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.