Cell state · L2
PC.IgA_muocsal.baseline
5,165 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ABCC9, COL4A1, COL4A2, CSPG4, DES, KCNJ8, MCAM, NOTCH3, PDGFRB, RGS5
Annotation genes
CSPG4, MCAM, PDGFRB, RGS5
Annotation rationales
The annotation genes define canonical pericyte identity and positioning on capillaries: PDGFRB drives pericyte recruitment/maintenance by PDGF-B from ECs; CSPG4 (NG2) marks perivascular coverage and process extension; MCAM (CD146) mediates EC–pericyte adhesion; RGS5 tunes GPCR signaling to adjust contractile responses. Co-expression of basement-membrane collagens (COL4A1/2) and K_ATP channel partners (ABCC9/KCNJ8) in the markers reinforces a homeostatic, tone-setting phenotype.
Functional implications
Provide continuous structural support and coverage of microvessels, sustaining endothelial quiescence, tight junction integrity, and basal vasomotor tone. Regulate capillary perfusion heterogeneity and blood–tissue barrier function (e.g., BBB/BRB equivalents) through rapid GPCR-mediated signaling (RGS5) and adhesive coupling (MCAM, CSPG4) under the instructive PDGF-B/PDGFRB axis.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.