Cell state · L2
MG.phagocytic_APC
1,178 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACTB, APOE, C1QA, C1QB, C1QC, CD63, CD68, CD74, CD81, CYBA, FCGR3A, HLA-DRB1, HLA-DRB5, LAPTM5, PLD4
Annotation genes
APOE, C1QA, CD68, CD74, HLA-DRB1
Annotation rationales
An antigen-presentation and high-clearance program: CD68, LAPTM5, PLD4, and CD63 denote enlarged lysosomal/endolysosomal systems; complement genes C1QA/C1QB/C1QC tag targets and shape synaptic pruning; APOE supports lipid shuttling after engulfment of myelin/synaptic membranes; upregulation of CD74 (invariant chain) and HLA-DRB1/DRB5 indicates functional MHC-II processing/presentation to CNS-infiltrating or meningeal T cells when barriers are breached. FCGR3A equips opsonic phagocytosis, while CYBA supports NADPH-oxidase–linked microbicidal/redox activity.
Functional implications
High-capacity debris/pathogen clearance and immune instruction: recognize and opsonize targets (complement C1QA complex), phagocytose and process antigens (CD68), then present peptides via HLA-DRB1 with CD74 chaperoning to tune local T-cell responses. In development and disease, refine synaptic circuits by complement-dependent pruning; during injury/infection, contain spread and coordinate adaptive immunity while metabolically buffering lipids through APOE to prevent bystander toxicity.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.