Cell state · L2
MG.expanding
649 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
NACA, RPL11, RPL12, RPL14, RPL19, RPL23A, RPL26, RPL32, RPL37, RPL37A, RPLP2, RPS15, RPS18, RPS24, RPS25, RPS27, RPS4X, RPS6, RPS8, TPT1
Annotation genes
RPL11, RPS6, TPT1
Annotation rationales
A translationally upshifted, cell-cycle-permissive state: broad induction of ribosomal subunits (e.g., RPL11, RPS6) and the growth/anti-apoptotic factor TPT1 indicates ramped protein synthesis to support proliferation, cytoskeletal remodeling, and secretory output. This profile commonly appears as microglia clonally expand near lesions or adapt to metabolic stress; RPS6 also reflects mTOR pathway engagement that fuels process outgrowth and phagolysosome biogenesis during activation.
Functional implications
Rapid pool expansion and phenotypic switching: locally proliferate to repopulate niches after neuronal/glial injury, scale up proteostasis and lysosomal components for forthcoming debris clearance, and prepare for state transitions (e.g., to phagocytic/APC microglia). Contribute to scar remodeling and restoration of homeostatic microglial density while minimizing excitotoxicity by timely resolution of the activated program.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.