Cell state · L2
MAC.resident_iron.APC_iron_sensing
1,628 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD302, CLEC10A, CPVL, FCGR2B, FCN1, FOLR2, HCST, HLA-DQA1, IFITM2, IFITM3, LYZ, SEC62, SLC40A1, TXNIP, VSIR
Annotation genes
CLEC10A, FCGR2B, FOLR2, HLA-DQA1, SLC40A1, TXNIP
Annotation rationales
HLA-DQA1/CLEC10A support antigen sampling/presentation; FCGR2B/VSIR deliver inhibitory signals; SLC40A1 exports iron; FOLR2 marks reparative macrophages; TXNIP couples redox to metabolism. Annotation genes define APCs tightly linked to iron flux.
Functional implications
Present iron-bearing antigens while exporting iron (SLC40A1) and restraining inflammation (FCGR2B/VSIR), preventing ferroptosis-driven tissue injury.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.