Cell state · L2
MAC.resident_cardiac.antigen_presenting
1,360 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD1C, CD74, CX3CR1, FLT3, HLA-DPA1, HLA-DRB1, IL18R1, TRAF3IP3
Annotation genes
CD1C, CD74, CX3CR1, HLA-DRB1, IL18R1
Annotation rationales
HLA-DRB1/CD74 enable MHC-II antigen loading; CD1C supports lipid antigen display; CX3CR1 marks long-lived patrollers; IL18R1 senses alarmins. Annotation genes define DC-like cardiac macrophages orchestrating T-cell responses.
Functional implications
Present cardiac/self and pathogen antigens to T cells, integrate IL-18 danger cues, and balance tolerance vs immunity to prevent autoimmune myocarditis while enabling antiviral defense.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.