Cell state · L2
MAC.proliferating.DNA_replication
834 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ANAPC11, CENPX, DEK, PCLAF, RANBP1, RPA3, SUMO2, TYMS
Annotation genes
ANAPC11, CENPX, PCLAF, RPA3, TYMS
Annotation rationales
PCLAF/RPA3/TYMS reflect active DNA synthesis; CENPX/ANAPC11 ensure chromosome/mitotic control. Annotation genes identify bona fide cycling macrophages expanding in situ.
Functional implications
Locally expand resident pools (e.g., Kupffer cells) after injury/infection to sustain phagocytic coverage and antigen-presenting capacity without relying solely on monocyte influx.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.