Cell state · L2
MAC.kupffer.tolerogenic
325 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ANKH, C1QA, C1QB, C1QC, CD163, EPB41L3, EXT1, GPR65, LILRB5, LIPA, MMD, MS4A4E, ORMDL1, PTPN6, RAB31, SLC40A1, SPRED1, SRGAP2, VSIG4
Annotation genes
C1QA, C1QB, CD163, LILRB5, SLC40A1, VSIG4
Annotation rationales
C1QA/B confer efferocytic/tolerogenic programming; CD163 promotes hemoglobin clearance; VSIG4 is a complement receptor with inhibitory signaling; LILRB5 adds checkpoint tone; SLC40A1 (ferroportin) exports iron. Annotation genes define iron-recycling, immune-quiet Kupffer cells.
Functional implications
Continuously clear apoptotic material and gut-derived antigens while recycling iron (SLC40A1), enforcing tolerance via VSIG4/LILRB5, and preventing inflammatory spillover into the liver.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.