Cell state · L2
MAC.kupffer.stress
474 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
DNAJB1, FCHO2, HMOX1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPB1, HSPE1, HSPH1, LGMN, MCOLN1, P4HA1, PPP1R15A, PTCH2, SLC26A11, TECR, UBB, UBC, ZFYVE16
Annotation genes
HMOX1, HSP90AA1, HSPA1A, PPP1R15A
Annotation rationales
HMOX1 detoxifies heme/iron, HSP90AA1/HSPA1A maintain proteostasis, PPP1R15A modulates ER-stress recovery. Annotation genes reflect cytoprotective adaptation to xenobiotics/oxidants.
Functional implications
Protect against heme/ROS injury from portal blood and hemolysis, preserving Kupffer viability and preventing sterile inflammation during toxic hits (alcohol/drugs).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.