Cell state · L2
MAC.kupffer.monocyte_like
233 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACAP1, ANKRD44, CKLF, CLEC10A, DGCR8, FLT3, HGF, JAML, MNDA, PLXNC1, SPSB3, TXNIP
Annotation genes
CLEC10A, FLT3, JAML, MNDA
Annotation rationales
FLT3/CLEC10A/MNDA indicate recent monocyte-to-Kupffer transition with antigen capture; JAML supports epithelial–immune junctions. Annotation genes denote a replenishing, surveillance-ready subset.
Functional implications
Refill depleted Kupffer niches post-injury, provide early antigen sampling (CLEC10A) and positioning (JAML), and mature toward tolerogenic or inflammatory fates depending on hepatic cues.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.