Cell state · L2
MAC.kupffer.metabolic
267 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD109, CD9, CHMP1B, DDIT4, FOSL2, GPAT3, GPR183, INSIG1, LFNG, LY9, MAT2A, NR4A3, RGS1, RPL10, SATB1, SLC2A3, STAB1, TFRC, VEGFA, ZNF331
Annotation genes
SLC2A3, STAB1, TFRC, VEGFA
Annotation rationales
TFRC denotes iron uptake; STAB1 marks scavenger/clearance function; SLC2A3 adapts glucose uptake; VEGFA suggests angiocrine support. Annotation genes reveal a Kupffer state integrating iron, energy, and endothelial crosstalk.
Functional implications
Buffer iron and fuel demands while signaling to endothelium (VEGFA) to preserve sinusoidal integrity; maintain scavenging (STAB1) and iron flux (TFRC) during fluctuating metabolic loads.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.