Cell state · L2
MAC.kupffer.inflammatory
317 cells in the full atlas (not the displayed sample).
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Marker genes
ABL2, BIRC3, CCL3, CCL4, CSF1, CXCL2, CXCL3, CXCL8, DCSTAMP, EMP1, ICAM1, IER3, MIR155HG, NRIP3, TNFAIP3
Annotation genes
CCL3, CCL4, CXCL8, ICAM1, MIR155HG, TNFAIP3
Annotation rationales
CCL3/4 and CXCL8 recruit monocytes/neutrophils; ICAM1 enhances adhesion; MIR155HG promotes pro-inflammatory polarization; TNFAIP3 is a feedback brake. Annotation genes typify activated Kupffer cells during sepsis/NASH.
Functional implications
Drive leukocyte trafficking to sinusoids, amplify inflammatory circuits, and, via TNFAIP3, prevent runaway hepatocellular damage—key early orchestrators of hepatic innate defense.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.