Cell state · L2
MAC.kupffer.fibrogenic
228 cells in the full atlas (not the displayed sample).
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Marker genes
ALMS1, ANKRD36C, BAZ1A, CD163L1, DDX24, FILIP1L, FYB1, IL1B, LINC00342, MYCBP2, MYO15B, MYO9A, PARP14, RCN3, RNF213, SAP25, SCO2, SNX6, TAGLN, ZNF532
Annotation genes
CD163L1, IL1B, RCN3, TAGLN
Annotation rationales
IL1B fuels stellate-cell activation; RCN3 assists collagen folding; TAGLN indicates actin/cytoskeletal remodeling consistent with tissue remodeling; CD163L1 supports scavenging during hemolysis. Annotation genes depict fibrogenic Kupffer activation.
Functional implications
Activate hepatic stellate cells via IL1B, promote scar ECM assembly (RCN3), and remodel sinusoidal niches (TAGLN), coupling inflammation to fibrosis in chronic liver injury.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.