Cell state · L2
MAC.alveolar.stress_metabolic
696 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CISH, FFAR4, FOS, GADD45B, GADD45G, HSPA2, KLF2, LYZ, PDK4, PTAFR, RGS2, TSC22D3, TXNIP
Annotation genes
KLF2, PDK4, PTAFR, TSC22D3, TXNIP
Annotation rationales
KLF2 and PDK4 couple metabolic reprogramming to low-O₂/fatty-acid use; PTAFR senses platelet-activating factor; TSC22D3 (GILZ) mediates glucocorticoid anti-inflammatory effects; TXNIP links redox/glucose stress. Annotation genes reflect acute environmental sensing with controlled inflammation.
Functional implications
Sense oxidants/allergens/PAF and rapidly recalibrate metabolism (PDK4/KLF2), engaging steroid-responsive brakes (TSC22D3) and redox control (TXNIP) to prevent exuberant inflammation in the alveoli.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.