Cell state · L2
MAC.alveolar.inflammatory
1,173 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACKR3, AQP9, CCL3, CCL4, CCRL2, CD101, CD69, CXCL5, IL1A, IL1RN, IL23A, IL6, MIR155HG, MMP19, MRC1, NLRP3, TNF, TNIP3
Annotation genes
CXCL5, IL1RN, IL6, NLRP3, TNF
Annotation rationales
TNF/IL6 drive NF-κB–mediated inflammation; CXCL5 recruits neutrophils to infected airspaces; NLRP3 signals inflammasome readiness; IL1RN provides an IL-1 brake to prevent tissue injury. Annotation genes together define an AM state that escalates but also self-limits inflammation.
Functional implications
Rapidly recruit neutrophils (CXCL5) and activate cytokine cascades (TNF/IL6) to clear pathogens while tempering IL-1 signaling (IL1RN) to protect delicate alveolar epithelium.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.