Cell state · L2
MAC.alveolar.capillary_interacting
560 cells in the full atlas (not the displayed sample).
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Marker genes
ANTXR2, ANXA6, BASP1, CLEC10A, CORO1A, CRIP2, FCGR2B, FCN1, GPR183, IGFBP7, KCNN4, PDGFB, PID1, PTGER2, RASSF2, RNASE1, SERPINB9
Annotation genes
CLEC10A, FCGR2B, PDGFB, PTGER2, RNASE1
Annotation rationales
CLEC10A supports antigen uptake, FCGR2B provides inhibitory Fc signaling to limit collateral damage, PTGER2 (PGE₂ receptor) enforces anti-inflammatory tone, PDGFB suggests crosstalk with endothelium/pericytes, and RNASE1 aids endothelial homeostasis. This constellation fits capillary-adjacent AMs that simultaneously sample antigens and stabilize the alveolar–capillary barrier.
Functional implications
Present antigens in a restrained fashion (via CLEC10A/FCGR2B), tune vascular permeability and tone (PDGFB), and leverage PTGER2/RNASE1 to quell edema/inflammation—coordinating immune surveillance with barrier protection during infection or ARDS.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.