Cell state · L2
MAC.MDM.inflammatory_phagocytic
1,853 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD300E, CLEC12A, FCAR, FCN1, HK3, LST1, LYST, RAB24, RIPOR2, S100A12, S100A8, S100A9, SLC11A1, STXBP2, TCF7L2, TCIRG1, UTRN
Annotation genes
CLEC12A, FCN1, S100A12, S100A8, S100A9, SLC11A1
Annotation rationales
S100A8/A9/A12 alarmins, FCN1 opsonin, SLC11A1 (NRAMP1) antimicrobial transport, and CLEC12A DAMP receptor define high-alert, pathogen-clearing MDMs. Annotation genes point to aggressive phagocytosis and cytokine production.
Functional implications
Rapidly phagocytose microbes/debris, trigger neutrophil recruitment via alarmins, and enhance microbicidal phagosome function (SLC11A1), providing frontline containment at inflamed barriers.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.