Cell state · L2
MAC.MDM.LAM_like
708 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
APOC1, APOC2, APOE, CD9, CSTB, CTSD, FABP4, FABP5, LGALS3, PLA2G7, SDC2, TREM2
Annotation genes
APOC1, APOE, FABP4, FABP5, PLA2G7, TREM2
Annotation rationales
TREM2 lipid-sensing, FABP4/5 fatty-acid shuttle, APOE/APOC1 lipid transport, PLA2G7 oxidized phospholipid catabolism—annotation genes mirror lipid-associated macrophages outside fat too.
Functional implications
Buffer lipids and oxidized debris in inflamed tissues, limit lipotoxicity, and coordinate tissue remodeling/fibrosis risk while modulating adaptive responses to lipid antigens.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.