Cell state · L2
MAC.MDM.APC_dendritic
1,453 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AFF3, CD1C, CD1E, CKLF, CLEC10A, CXCR4, EZR, FCER1A, GPAT3, IL1R2, INSIG1
Annotation genes
CD1C, CD1E, CLEC10A, CXCR4, FCER1A
Annotation rationales
CD1C/CD1E enable lipid-antigen presentation to T cells; CLEC10A/FCER1A enhance antigen capture; CXCR4 guides positioning in lymphoid niches. Annotation genes define a DC-like macrophage bridging innate/adaptive immunity.
Functional implications
Capture and present (lipid) antigens to naïve/effector T cells, migrate/position to T-cell zones (CXCR4), and shape Th responses while retaining macrophage phagocytic capacity.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.