Cell state · L2
IPSC.stromal_primed
6,156 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ARL4C, CFAP69, COL14A1, DMTN, GREB1L, HOXB9, LRIG3, MCM6, PRKG1, SERINC5, SOX2, STEAP1, ZNRF3
Annotation genes
COL14A1, HOXB9, SOX2, ZNRF3
Annotation rationales
COL14A1 (FACIT collagen) and ZNRF3 (WNT receptor ubiquitin ligase) indicate ECM remodeling with tuned WNT responsiveness; HOXB9 introduces posterior stromal patterning while SOX2 persistence confirms partial pluripotency retention. These Annotation genes summarize a stromal-leaning yet still plastic iPSC state.
Functional implications
Acts as an ECM-conditioning intermediate that improves adhesion/tissue mimicry in 2D/3D systems and can be redirected back to epithelium or mesenchyme depending on WNT/TGF-β cues; useful for co-culture niche engineering before terminal differentiation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.