Cell state · L2
IPSC.stress
1,816 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADM, DUSP5, HMOX1, HSPA1A, HSPH1, KCNF1, MAFF, PPP1R15A, YRDC, ZFAND2A
Annotation genes
DUSP5, HMOX1, HSPA1A, PPP1R15A
Annotation rationales
Heat-shock HSPA1A/HSPH1, oxidative-defense HMOX1, ER/translation brake PPP1R15A (GADD34), and MAPK feedback DUSP5 define a stress-adaptive iPSC state often triggered by passaging or high-density culture. These Annotation genes denote proteostasis and redox buffering required to preserve genome/pluripotency integrity.
Functional implications
Transiently halts lineage commitment and stabilizes proteome/ROS during culture stress; when relieved, re-enters standard pluripotency or proceeds to differentiation with reduced apoptosis and fewer off-target fates.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.