Cell state · L2
IPSC.neuroendocrine_primed
119 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CERKL, CPLX2, DCC, DCX, DRD2, EBF2, EBF3, EYA2, INSM1, NEUROD1, NEUROD4, NEUROG3, NHLH1, NPY, P2RX3, RGR, SSTR2, SUSD2, ZNF385D
Annotation genes
DCX, INSM1, NEUROD1, NEUROG3, NPY
Annotation rationales
Endocrine/neural TFs NEUROD1/NEUROG3 and INSM1 indicate endocrine/neuroendocrine specification; DCX marks neuronal migration competence; NPY denotes neuropeptide lineage. These Annotation genes together define a state frequently exploited to generate islet/enteroendocrine or neuroendocrine neurons in vitro.
Functional implications
Drives endocrine/neuroendocrine programs (e.g., pancreatic/intestinal endocrine cells or hypothalamic-like neurons) upon stage-specific Notch/RA/FGF tuning; enhances hormone/peptide-secreting lineage yields for disease modeling and secretion assays.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.