Cell state · L2
IPSC.midbrain_primed
1,442 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CNTN2, CNTNAP2, GALNT10, GLI3, GRPR, IGFBP3, ISM1, LHX5, LLGL2, LMO1, NRIP3, OTX1, OTX2, SHISA2, SORCS2, TPBG, ZFHX4
Annotation genes
GLI3, LHX5, OTX1, OTX2
Annotation rationales
Midbrain–hindbrain patterning is indicated by OTX1/OTX2 (anterior neuroectoderm), LHX5 (forebrain/midbrain TF), and GLI3 (Hedgehog pathway), defining a neural plate–like iPSC subset already regionally specified. Mentioning these Annotation genes underscores readiness for dopaminergic patterning.
Functional implications
Rapidly yields midbrain floor-plate and dopaminergic neuron progenitors with SHH/FGF8 cues; supports scalable production of neuronal subtypes for disease modeling (e.g., PD) and high-content screening.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.