Cell state · L2

IPSC.mesodermal_primed

1,329 cells in the full atlas (not the displayed sample).

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Marker genes

ABCG1, AIF1, CITED1, DLL3, ENPP2, FABP5, FGF9, FOXC1, ITM2A, MIXL1, MME, MSGN1, NKG7, PDGFRA, RSPO3, S1PR3, ST8SIA6, TBX6, TNFSF11A, VWA2

Annotation genes

FGF9, MIXL1, MSGN1, PDGFRA, TBX6

Annotation rationales

Primitive streak/mesoderm TFs MIXL1, MSGN1, TBX6 with PDGFRA (mesoderm marker) and FGF9 (paracrine driver) denote paraxial/somite-leaning mesoderm. These Annotation genes are canonical readouts of in vitro mesoderm patterning.

Functional implications

Seeds paraxial mesoderm that differentiates into sclerotome/dermomyotome derivatives (e.g., skeletal muscle, tendon, cartilage) under WNT/SHH/BMP modulation; improves efficiency of myogenic and chondrogenic protocols.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.