Cell state · L2
IPSC.mesendo_primed
10,551 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CDC42EP5, CLDN11, DPEP1, GPM6A, GREB1, HOXC4, IGF2, NEFM, PDE4B, PROCR, SCG5, SULT1C4, TGFA, VAMP8, WFDC2
Annotation genes
HOXC4, IGF2, PROCR, TGFA
Annotation rationales
PROCR marks mesendodermal progenitors; IGF2 and TGFA indicate a trophic milieu that supports proliferation and epithelial–mesenchymal cross-talk; HOXC4 provides axial patterning input. Together these Annotation genes define a poised state that can yield vascular/endodermal derivatives depending on WNT/Activin titration.
Functional implications
Provides a flexible mesendodermal starting point that efficiently bifurcates toward endothelial/hepatic or early mesoderm fates in vitro; useful for generating vascular organoids or hepatic progenitors via fine-tuned WNT/Activin/FGF gradients.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.