Cell state · L2
IPSC.mesenchymal_primed
9,987 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ABCA1, ADAMTS2, ATCAY, ATP1A2, CDON, COL1A1, COL1A2, DLK1, FRY, IGFBP5, KIFC3, LRP2, MIR503HG, OLFM2, PLLP, SFRP1, THBS2, ZIC3
Annotation genes
ADAMTS2, COL1A1, COL1A2, IGFBP5, THBS2
Annotation rationales
ECM assembly genes COL1A1/COL1A2 with crosslinking/processing ADAMTS2 and matricellular THBS2, plus stromal growth factor IGFBP5, denote a mesenchymal-like transition (partial EMT) frequently seen during iPSC drift or mesoderm induction. These Annotation genes capture collagenous matrix competence and stromal paracrine capability.
Functional implications
Acts as a stromal/mesenchymal-biased intermediate that remodels matrix and supports subsequent mesoderm derivatives (fibroblast, chondro/tenogenic, perivascular). Improves attachment and survival during early mesoderm induction and can seed scaffold-based tissue engineering.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.