Cell state · L2
IPSC.canonical_pluripotent
7,499 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ASS1, GDAP1L1, POU5F1, PPP1R1A, VAT1
Annotation genes
ASS1, POU5F1
Annotation rationales
High POU5F1 (OCT4) defines the core pluripotent network; co-expression of ASS1 points to a characteristic amino-acid/urea-cycle–linked metabolic state seen in naïve/primed stem cells that buffers nitrogen and supports anabolic growth. The persistence of this transcriptional-metabolic duet (POU5F1, ASS1) reflects self-renewal without lineage bias, ideal for maintenance culture.
Functional implications
Maintains self-renewal and epiblast-like plasticity in vitro, supporting high cloning efficiency and readiness to enter any germ-layer program once exogenous patterning signals (e.g., Activin/Nodal, BMP, WNT) are applied.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.