Cell state · L2
FIB.tracheal_subepithelial.baseline
181 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BMP7, CRABP1, DLL1, ENTPD1, FOXF2, IL24, PI15, WNT5A
Annotation genes
BMP7, CRABP1, DLL1, ENTPD1, FOXF2, WNT5A
Annotation rationales
Airway subepithelial fibroblasts orchestrate mucociliary patterning. WNT5A/BMP7 balance planar polarity/ciliogenesis; DLL1 delivers Notch to basal cells to set secretory/ciliated ratios; CRABP1 channels retinoids essential for mucin/CC10 regulation; ENTPD1 degrades extracellular ATP to curb purinergic inflammation; FOXF2 secures mesenchymal identity.
Functional implications
Provides a morphogen/retinoid niche that maintains epithelial composition and dampens ATP-driven cough/inflammation; keeps pericellular ECM compliant for ciliary beating and efficient repair after irritation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.