Cell state · L2
FIB.suburothelial.inflammatory_prostanoid
173 cells in the full atlas (not the displayed sample).
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Marker genes
CD40, CX3CL1, ICAM1, IFI30, IL32, MT1A, MT1E, MT1M, MT2A, NFKB2, PTGES, RELB, SLC39A14, SOD2, TNFAIP2, TNFSF10, TSLP, UAP1, UGCG
Annotation genes
CX3CL1, ICAM1, NFKB2, PTGES, RELB, TSLP
Annotation rationales
Alternative NF-κB (NFKB2/RELB) drives a chronic-like inflammatory program; PTGES produces PGE2/PGE-series prostanoids; CX3CL1/ICAM1 coordinate leukocyte retention; TSLP engages epithelial danger circuits.
Functional implications
Acts as a cytokine/prostanoid hub during cystitis: sustains leukocyte–stromal interactions, sensitizes nerves/urothelium, and modulates pain/urgency while attempting to cap tissue damage.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.