Cell state · L2
FIB.skin_sheath.stress_chaperone
167 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ASPN, BTG2, COCH, DNAJA1, EMP1, HMOX1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPE1, HSPE1-MOB4, JUN, NR4A1, OGN, PPP1R15A, SERTAD1, UBC
Annotation genes
ASPN, HMOX1, HSP90AB1, HSPA1A, HSPA1B, JUN, NR4A1, OGN
Annotation rationales
Sheath fibroblasts confront mechanical shearing; HSPs/HSF targets protect proteome; HMOX1 and JUN/NR4A1 indicate oxidative and IEG stress coping. ASPN/OGN (SLRPs) tailor fibrillogenesis under load; EMP1 strengthens cell–matrix attachment.
Functional implications
Provides immediate proteostasis protection and rapidly retunes collagen fibril organization to prevent tears during motion/inflammation—maintaining follicle anchorage and skin mechanics.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.