Cell state · L2
FIB.skin_sheath.ECM_immune
151 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
APOD, C1R, C1S, CDKN1A, CFH, COL6A2, CXCL12, CXCL2, HES1, HLA-A, HLA-B, IL32, NAMPT, POSTN, SOD2, TMEM176A, TNFAIP6
Annotation genes
C1R, C1S, CFH, COL6A2, CXCL12, HES1, POSTN, TNFAIP6
Annotation rationales
Hair-follicle sheath fibroblasts endure tensile stress. COL6A2/POSTN reinforce pericellular matrix; CXCL12 creates a niche for neurovascular partners; complement components (C1R/1S) with CFH regulation allow microbial control without collateral damage. TNFAIP6 stabilizes HA; NAMPT/SOD2 equip metabolic/ROS resilience.
Functional implications
Maintains a strong, flexible sheath that anchors arrector pili and vessels/nerves; orchestrates immune surveillance without follicle damage; stabilizes HA to lubricate movement and facilitate low-inflammation repair.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.