Cell state · L2
FIB.reticular.stromal_niche
671 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ABCA8, APOC1, APOD, CCDC80, CXCL12, EFEMP1, EGR1, FOSB, GGT5, IGFBP3, IGFBP7, IL11RA, IL33, ITM2A, RHOB, TXNIP
Annotation genes
CXCL12, EFEMP1, IGFBP3, IGFBP7, IL33
Annotation rationales
CXCL12⁺ fibroblasts create migratory corridors for immune/progenitor cells. IGFBP3/7 meter mitogens; IL33 primes type-2 immunity and tissue repair; EFEMP1 shapes elastic micro-architecture.
Functional implications
Maintains a chemokine/growth-factor reservoir that positions cells for surveillance and repair; issues IL-33 alarms upon injury; preserves elasticity at the dermal base to support appendage growth and wound re-epithelialization.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.