Cell state · L2
FIB.reticular.ECM_builder
199 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ACKR4, CD9, COMP, DIRAS3, FBLN1, HSPB3, MFAP2, MMP2, PCO LCE2, PLPP3, SFRP2, WIF1
Annotation genes
COMP, FBLN1, MFAP2, MMP2, SFRP2
Annotation rationales
Deep dermal (reticular) fibroblasts synthesize dense collagen and elastic fiber connectors (COMP/FBLN1/MFAP2). MMP2 allows controlled turnover; SFRP2/WIF1 temper Wnt to regulate fibril patterning; ACKR4 can scavenge chemokines in matrix.
Functional implications
Builds tensile dermis and manages long-term collagen alignment; replaces fatigued fibers and sets biomechanical properties for skin resilience and wound strength.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.