Cell state · L2
FIB.perivascular_interface.vasomotor_tone
208 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
APCDD1, BCL2L11, ECE1, EMP1, GAS8, GNPNAT1, IGFBP2, MFSD14A, PSMC1, SMARCA2
Annotation genes
APCDD1, ECE1, EMP1, GNPNAT1, IGFBP2
Annotation rationales
Produces endothelin locally (ECE1) and communicates directly with endothelium (EMP1). APCDD1 restrains Wnt-driven angiogenesis; IGFBP2 modulates IGF for mural cell behavior; GNPNAT1 fuels hexosamine biosynthesis for glycocalyx/proteoglycans.
Functional implications
Tunes microvascular constriction/permeability and leukocyte rolling by adjusting endothelin, Wnt, and glycocalyx composition—key for esophageal microvessel tone during irritation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.