Cell state · L2
FIB.neurolectin_mucosa.inflammatory
485 cells in the full atlas (not the displayed sample).
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Marker genes
C11orf96, CCL2, CDKN1A, CEBPB, CEBPD, CSRNP1, CXCL2, GEM, ICAM1, IRF1, JUNB, MYC, NAMPT, PNRC1, PPP1R15A, SOCS3, SOD2, THBS1, ZFP36, ZNF331
Annotation genes
CCL2, CEBPD, CXCL2, ICAM1, IRF1, SOCS3, ZFP36
Annotation rationales
Neuro-mucosal fibroblasts launch chemokine bursts (CCL2/CXCL2) and adhesion (ICAM1) to recruit/retain leukocytes. SOCS3/ZFP36 provide rapid signal shut-off; NAMPT/SOD2 couple metabolic defense to inflammation.
Functional implications
Orchestrates acute flares by calling in neutrophils/monocytes, then actively resolves by damping signaling. Shapes the balance between protective inflammation and tissue irritation-induced pain.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.